SCF-Fbxo42 promotes synaptonemal complex assembly by downregulating PP2A-B56
نویسندگان
چکیده
منابع مشابه
PP2A-B56 opposes Mps1 phosphorylation of Knl1 and thereby promotes spindle assembly checkpoint silencing
The spindle assembly checkpoint (SAC) monitors correct attachment of chromosomes to microtubules, an important safeguard mechanism ensuring faithful chromosome segregation in eukaryotic cells. How the SAC signal is turned off once all the chromosomes have successfully attached to the spindle remains an unresolved question. Mps1 phosphorylation of Knl1 results in recruitment of the SAC proteins ...
متن کاملPP2A-B56 opposes Mps1 phosphorylation of Knl1
Mps1-dependent spindle assembly checkpoint (SAC) signaling delays anaphase entry until all chromosomes have been correctly attached to the mitotic spindle (Foley and Kapoor, 2013). Knl1 is the kinetochore localized binding partner for the SAC proteins Bub1, BubR1, and Bub3 (Kiyomitsu et al., 2007). Phosphorylation of Knl1 by Mps1 is a prerequisite for the interaction of Bub1 and Bub3 with Knl1 ...
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During meiosis, homologous chromosomes pair at close proximity to form the synaptonemal complex (SC). This association is mediated by transverse filament proteins that hold the axes of homologous chromosomes together along their entire length. Transverse filament proteins are highly aggregative and can form an aberrant aggregate called the polycomplex that is unassociated with chromosomes. Here...
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Proper alignment of duplicated chromosomes at the metaphase plate involves both motor-driven chromosome movement and the functional and physical end-on connection (K-fiber formation) between the kinetochore and the plus-end of microtubules. The B56 family of protein phosphatase 2A (PP2A) regulatory subunits (B56-PP2A), through their interaction with the mitotic checkpoint protein BUBR1, are req...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2020
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.202009167